Science @ Columbia


Researchers at Columbia University Medical Center (CUMC) have demonstrated that a protein called caspase-2 is a key regulator of a signaling pathway that leads to cognitive decline in Alzheimer’s disease.

The leftmost image – WT (wildtype), or normal, mice – shows normal branching of neuronal dendrites. The mice with Alzheimer’s disease (J20) show significant dendritic loss. When caspase-2 was deleted from mice with Alzheimer’s (J20/Casp2KO), dendritic branching was normal–demonstrating that removal of caspase-2 can protect neurons in the presence of amyloid beta.

Image credit: Julio Pozueta

#CUMC   #IFTTT   #neurons   #dendrites   #Alzheimer's   #protein  

11 notes

  1. bluefreakincake reblogged this from columbiascience
  2. watchtowertoarrow reblogged this from ipodsforalzheimers
  3. wisteria-prince reblogged this from ipodsforalzheimers
  4. ipodsforalzheimers reblogged this from columbiascience
  5. drtgr02 reblogged this from columbiascience
  6. starlightwaters reblogged this from columbiascience
  7. columbiascience posted this
blog comments powered by Disqus